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. 2021 Sep 21;53(9):1379–1389. doi: 10.1038/s12276-021-00671-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a t-SNE plots of the Mo/MΦ subpopulations (Mo/MΦ_1, Mo/MΦ_2, Mo/MΦ_3, Mo/MΦ_4) from the ND (1991 cells) and HFD (731 cells) groups. b Percentages of Mo/MΦ subpopulations from the ND (Mo/MΦ_1, 82%; Mo/MΦ_2, 9%; Mo/MΦ_3, 6%; and Mo/MΦ_4, 3%) and HFD (Mo/MΦ_1, 80%; Mo/MΦ_2, 15%; Mo/MΦ_3, 4%; and Mo/MΦ_4, 1%) groups. c Heatmap of the top 20 marker genes per subpopulation. d Violin plots of signature genes confirming the subpopulation identities. e–h Top 10 pathways associated with the Mo/MΦ_1 (e), Mo/MΦ_2 (f), Mo/MΦ_3 (g), and Mo/MΦ_4 (h) clusters. i Violin plots of the differential expression of chemokine- and receptor-associated genes by Mo/MΦ subpopulation. j Expression of chemokine- and receptor-associated genes for Mo/MΦ subpopulations as visualized by dot plot.