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. 2021 Oct 5;11:19707. doi: 10.1038/s41598-021-99227-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunogenic potential of the designed vaccine (DV-1). In response to the exposure of DV-1 after three injections, (A) production of immunoglobulins (B) active B-cell populations/state; (C) plasma B-lymphocytes and their isotypes per state; (D) helper T-cell population/state; (E) cytotoxic T-cell population/state; (F) reduction in the level of T regulatory cells; (G) dendritic cell population per state; (H) activity of macrophage population/state; (I) cytokine level and interleukins (smaller plot) in different states with the Simpson index (dotted line). All units are in cells/mm³ in three subsequent immune responses.