Table 10.

The binding properties of the docking analysis using PATHDOCK and refined by FIREDOCK.

Vaccine construct	Receptor	Name of target	Score	Area	H-bond E	Global E	ACE
DV-1	5WJL	HLA-A*11–01	10,204	14.12.80	− 4.81	− 60.07	− 114.00
	5JLZ	HLA-DRB1*04–01	10,056	1240.30	− 2.19	− 51.02	− 140.36
	3FXI	TLR2	15,766	2591.40	− 3.20	− 63.40	− 33.79
	2Z7X	TLR4	16,202	1880.60	− 5.73	− 69.89	103.14
DV-2	5WJL	HLA-A*11–01	9098	1523.60	− 1.90	− 48.11	145.04
	5JLZ	HLA DRB1*04–01	9072	1387.70	− 1.24	− 59.30	− 89.11
	3FXI	TLR2	15,784	2264.40	− 1.14	− 47.31	162.29
	2Z7X	TLR4	17,282	2301.00	− 1.69	− 50.15	13.11
DV-3	5WJL	HLA-A*11–01	10,162	1642..20	− 2.51	− 41.64	307.70
	5JLZ	HLA DRB1*04–01	10,740	1373.90	− 3.83	− 63.84	− 111.34
	3FXI	TLR2	15,328	1816.70	− 4.09	− 45.59	182.27
	2Z7X	TLR4	15,214	1893.10	− 2.17	− 60.23	121.10
DV-4	5WJL	HLA-A*11–01	10,444	2290.20	− 3.85	− 57.16	256.86
	5JLZ	HLA DRB1*04–01	10,350	1326.40	− 3.48	− 67.22	− 196.17
	3FXI	TLR2	15,726	2291.70	− 5.90	− 52.53	− 99.35
	2Z7X	TLR4	15,420	3052.30	− 6.31	− 50.39	464.55

H-Bond E Hydrogen bond energy; Global E Global energy, ACE Atomic contact energy

*Allelic variants.