Fig. 5. TAZ prevented mitochondrial dysfunction and stromal cell apoptosis under OS.

a Overexpression of TAZ decreased mitochondrial O₂⁻ level under OS. b–d Overexpression of TAZ hindered H₂O₂-induced damage to ATP level, mtDNA copy number, and mitochondrial membrane potential. e Effects of TAZ overexpression on the activities of mitochondrial respiratory chain complexes I, II, and III under OS. f, g ROT and AA abrogated the protection conferred by TAZ overexpression on stromal cell differentiation under OS. h Overexpression of TAZ blocked stromal cell apoptosis under OS. i, j Overexpression of TAZ weakened Casp3 activity, reduced the levels of Casp3 and Bax mRNA and induced the recovery of Bcl2 expression under OS.