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. 2021 Oct 5;12:5838. doi: 10.1038/s41467-021-26118-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Fc fucosylation levels of total plasma IgG1 (gray, n = 72) and IgG1 with specificity for VAR2CSA (orange, n = 50), VAR6 (green, n = 65), and GLURP (blue, n = 43) in non-pregnant Ghanaian women exposed to VAR2CSA during one or more previous pregnancies. Fc fucosylation levels of total plasma IgG1 from unexposed Dutch females (n = 5) are included as controls. Medians and densities are shown. Statistically significant pairwise differences between antigen-specific IgG and total IgG (multiple two-sided Wilcoxon signed-rank tests with Bonferroni correction) are indicated (****P < 0.0001). b Correlation between fucosylation levels of VAR2CSA-specific IgG1 and parity. c Correlation between fucosylation levels of VAR2CSA-specific IgG1 and time since last pregnancy. Statistical significance of correlations are shown (Spearman’s correlations. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).