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. 2021 Oct 5;12:5838. doi: 10.1038/s41467-021-26118-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a VAR2CSA-specific IgG fucosylation levels of samples with low (open symbols) and high fucose (filled symbols) levels. b Comparison of VAR2CSA-specific IgG levels and c CD107a expression between highly fucosylated (filled symbols) and afucosylated anti-VAR2CSA IgG1 (open symbols) samples, respectively. Mean from three independent experiments and P values from two-sided Mann–Whitney tests are shown. d VAR2CSA-specific, human monoclonal antibody PAM1.4 as either fucosylated or afucosylated IgG1 was titrated in the same assay and VAR2CSA-binding or e degranulation activity (CD107a expression) on NK92-CD16a cells was measured. IgG: non-immune human IgG. Data represent mean values ± SD from three independent experiments.