Table 3.
Primary outcome domains and statistical significance (α ≤ 0.05) of the included studies (n = 56).
| Core area | Outcome domain | Positive results | Neutral results | Negative results |
|---|---|---|---|---|
| II. Clinical outcomes | 3. Cardiac outcomes | 3 | 0 | 0 |
| 5. Endocrine outcomes | 7 | 13 | 0 | |
| 9. General outcomes | 1 | 0 | 0 | |
| 14. Metabolism and nutrition outcomes | 1 | 0 | 0 | |
| 22. Respiratory, thoracic and mediastinal outcomes | 0 | 4 | 0 | |
| III. Life impact | 25. Physical functioning | 2 | 5 | 0 |
| 28. Emotional functioning/wellbeing | 2 | 1 | 0 | |
| 29. Cognitive functioning | 1 | 0 | 0 | |
| 30. Global quality of life | 2 | 3 | 0 | |
| 32. Delivery of care | 5 | 2 | 0 | |
| IV. Resource use | 34. Economic | 0 | 1 | 0 |
| 35. Hospital | 0 | 1 | 0 | |
| 27. Societal/care burden | 1 | 0 | 0 | |
| V. Adverse events | 38. Adverse events/effects | 0 | 1 | 0 |