. Author manuscript; available in PMC: 2022 Mar 12.

Published in final edited form as: Pediatr Res. 2021 Apr 6;91(3):529–538. doi: 10.1038/s41390-021-01499-2

Table 2:

Example drug-gene pairs for medications prescribed to children with significant evidence for recommendations in prescribing actions as defined by the Clinical Pharmacogenetics Implementation Consortium

Drug	Gene
allopurinol	HLA-B
aminoglycoside antibacterials	MT-RNR1
amitriptyline	CYP2C19
amitriptyline	CYP2D6
atomoxetine	CYP2D6
azathioprine	TPMT
azathioprine	NUDT15
carbamazepine	HLA-A
carbamazepine	HLA-B
citalopram	CYP2C19
clopidogrel	CYP2C19
codeine	CYP2D6
escitalopram	CYP2C19
fluvoxamine	CYP2D6
ibuprofen	CYP2C9
lansoprazole	CYP2C19
mercaptopurine	TPMT
mercaptopurine	NUDT15
nortriptyline	CYP2D6
omeprazole	CYP2C19
ondansetron	CYP2D6
pantoprazole	CYP2C19
paroxetine	CYP2D6
phenytoin	HLA-B
phenytoin	CYP2C9
sertraline	CYP2C19
simvastatin	SLCO1B1
succinylcholine	RYR1
succinylcholine	CACNA1S
tacrolimus	CYP3A5
tramadol	CYP2D6
voriconazole	CYP2C19
warfarin	CYP2C9
	CYP4F2
	VKORC1