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. 2021 Oct 5;12(10):908. doi: 10.1038/s41419-021-04209-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Schematic diagram of the screening process for miRNAs with significant differential expression using microRNA sequencing data; (B) Heat map of miRNA expression of 18 miRNAs with significant differences of 4-fold or more. The red text indicates that the candidate miRNA has not been discussed for its potential mechanism or role in leukemia. Green text means that the miRNA has been confirmed in several papers for its role in leukemia. C The expression of candidate miRNAs in PBMC of CML patients and healthy donors was confirmed by qPCR, and U6 was used as an internal control. Each data represents mean ± SD from independent experiments performed in triplicate. Statistical significance analysis was performed with Student’s t-test. *P < 0.05; **P < 0.01.