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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Semin Cancer Biol. 2021 Apr 6;85:107–122. doi: 10.1016/j.semcancer.2021.04.003

Figure 4. Multiple strategies for inhibiting Hh signal transduction pathway.

Figure 4.

Hh signal transduction can be blocked at multiple steps including Hh inhibitors that either inhibit the activity of Hh acyltransferase (Hhat) or directly bind and inhibit Hh, Smo inhibitors, Gli inhibitors as well as pathway modulators that inhibit Gli by regulating its kinases or binding partners. See text for details.