Fig. 3.

Mean values ± SEM expressed as nmoles/ml plasma of endocannabinoidome mediators. N-acyl-ethanolamines (a) and 2-monoacyl-glycerol (b) in 42 octogenarians (> 80 years) from an area of Sardinia that possesses a strikingly high level of long-living people (Old-HLZ); 21 subjects (65–70 years) from the same zone (Young-HLZ) and 22 octogenarians (> 80 years) from a different area with a distinctly lower level of longevity (Old-LLZ). To assess the statistical significance between groups, we performed the Kruskal-Wallis test (one-way ANOVA on ranks) followed by Dunn’s correction for multiple comparisons. Different letters indicate significant differences amongst groups (p≤0.05). Anandamide (AEA), palmitoyl-ethanolamide (PEA), oleoyl-ethanolamide (OEA), docosahexaenoyl-ethanolamide (DHAEA), 2-arachidonoyl-glycerol (2-AG), 2-palmitoyl-glycerol (2-PG), 2-linoleoyl-glycerol (2-LG), 2-oleoyl-glycerol (2-OG)