Table 1.
Characteristics of study participants by age at round 1
| 30 years | 40 years | 50 years | 60 years | |
|---|---|---|---|---|
| n = 547 | n = 622 | n = 612 | n = 395 | |
| Demographics and lifestyle | ||||
| Age (years) | 30.8 (30.6–31.0) | 40.8 (40.6–40.9) | 50.8 (50.6–50.9) | 60.8 (60.6–60.9) |
| Male (%) | 260 (47.5) | 304 (48.9) | 313 (51.1) | 171 (43.3) |
| Daily smoker (%) | 298 (54.5) | 292 (47.0) | 319 (52.1) | 145 (36.7) |
| BMI (kg/m2) | 22.3 (20.6–24.5) | 23.7 (21.8–26.3) | 24.8 (22.7–27.4) | 25.0 (22.8–27.2) |
| Physical activity level | ||||
| Almost completely inactive (%) | 145 (26.5) | 161 (25.9) | 144 (23.5) | 82 (20.8) |
| Some physical activity (%) | 273 (49.9) | 299 (48.1) | 336 (54.9) | 234 (59.2) |
| Regular activity (%) | 107 (19.6) | 148 (23.8) | 131 (21.4) | 79 (20.0) |
| Regular hard physical training (%) | 22 (4.0) | 14 (2.3) | 1 (0.2) | 0 (0.0) |
| Cardiovascular risk factors | ||||
| Diabetes (%) | 2 (0.4) | 7 (1.1) | 12 (2.0) | 8 (2.0) |
| Cardiovascular disease (%) | 10 (1.8) | 13 (2.1) | 21 (3.4) | 22 (5.6) |
| Hypertension (%) | 56 (10.2) | 83 (13.3) | 84 (13.7) | 79 (20.0) |
| Total cholesterol (mmol/L) | 5.2 (4.7–5.8) | 5.7 (5.1–6.5) | 6.3 (5.6–7.0) | 6.7 (6.0–7.5) |
| HDL cholesterol (mmol/L) | 1.4 (1.2–1.7) | 1.5 (1.2–1.8) | 1.5 (1.2–1.8) | 1.6 (1.3–1.9) |
| Biomarkers of organ function | ||||
| CRP (mg/L) | 0.8 (0.4–1.7) | 0.9 (0.5–1.9) | 1.3 (0.6–2.8) | 1.7 (0.8–3.2) |
| Cystatin C (mg/L) | 0.7 (0.6–0.7) | 0.7 (0.6–0.7) | 0.7 (0.7–0.8) | 0.8 (0.7–0.9) |
| eGFR (mL/min/1.73m2) | 115.3 (105.3–119.7) | 106.5 (97.2–111.2) | 97.6 (85.3–103.5) | 87.8 (76.7–95.6) |
| AST (U/L) | 25.0 (19.9–31.0) | 25.0 (20.0–31.74) | 26.0 (21.0–32.0) | 29.0 (23.0–35.0) |
| GGT (U/L) | 18.0 (14.0–30.0) | 21.0 (14.0–35.0) | 24.0 (16.49–42.0) | 26.0 (18.0–40.0) |
| hs-cTnI (ng/L) | 2.3 (1.4–3.6) | 2.2 (1.3–3.4) | 2.3 (1.4–3.5) | 3.1 (2.1–4.8) |
Data are presented as median (interquartile range) or n (%).
AST, aspartate transaminase; BMI, body mass index; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; hs-cTnI, high-sensitive troponin I; GGT, gamma-glutamyl transferase