Table 2.
Metallothionein (MT) in long-lived mouse models (fold-change vs. controls)
| Model | MT | Sex | Strain | Age | Method | Reference |
|---|---|---|---|---|---|---|
| Kidney | ||||||
| GHRKO | 1.7 | Male | C57BL/6 J | Adult | qPCR | Swindell et al. [77] |
| Ames dwarf | 1.9 | Male | Mixed | 12 mo | qPCR | This manuscript |
| MT-Tg | 4.7 | Male | C57BL/6 J | 7–10 wks | Cd/Hb | Iszard et al. [37] |
| Liver | ||||||
| Rapamycin | 0.1 | Female | UM-HET3 | 12 mo | qPCR | Miller et al. (unpublished) |
| CR | 1.8 | Female | UM-HET3 | 12 mo | qPCR | Miller et al. (unpublished) |
| GHRKO | 6.2 | Male | C57BL/6 J | 12 mo | qPCR | Swindell et al. [77] |
| Ames dwarf | 7.7 | Female | Mixed | 3 mo | qPCR | This manuscript |
| MT-Tg | 8 | Male | C57BL/6 J | 7–10 wks | Protein | Iszard et al. [37] |
This table provides estimates from the literature (unless they are from this work as indicate in the column Reference) of MT expression in long-lived mice and their control. We present data for animals of the same sex as those we used for Cd analyses. Although we do not have data for kidney MT in female Ames dwarf, we assume it is higher based on the liver data. MT represents the mean of changes in MT-1 and MT-2. Cd/Hb, Cd/hemoglobin assay; mo, months; d, days; wks, weeks