Fig. 2.

Effects of age and sex on medial prefrontal cortex (MPFC, left column) and striatal (right column) metabolite levels for glutamate (Glu), GABA, glutathione (GSH), and taurine (Tau). Shown are means + SEMs of 10-13 observations per group. GABA and taurine levels were lower in both brain regions in older mice and MPFC Glu levels were lower in older mice. MPFC GSH levels were lower in older female mice and taurine levels in both brain areas were lower in female mice. Asterisk indicates a main effect of sex. Dagger indicates a main effect of age. Double dagger indicates an interaction wherein older females differ from older males, p < 0.05