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. 2021 Oct 5;11:19714. doi: 10.1038/s41598-021-98970-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Model of adipocyte differentiation. Growth factors and second messengers lead to the production of C/EBP-β, which feeds into production of PPARγ and subsequent production of adipogenic factors including ap2, Adiponectin, and Sgk-1, whose action together leads to terminal differentiation of preadipose fibroblast cells to adipocytes. Activity of 5-HT_2A receptors is necessary for production and/or activity of PPARγ, downstream of C/EBP-β, to induce production of proadipogenic factors and terminal differentiation.