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. 2021 Oct 5;11:19763. doi: 10.1038/s41598-021-99162-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Goodness of fit plots. The black line represents the identity line. Blue circles represent the observed concentrations versus the corresponding predicted concentrations. The yellow line represents the trend line. Left panel: plot of the observed plasma concentrations (mg/L) versus population predicted plasma concentrations (PRED) (no random component). Right panel: plot of the observed plasma concentrations (mg/L) versus individual predicted plasma concentration values (IPRED) (with random component).