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. 2021 Sep 29;53(9):1437–1448. doi: 10.1038/s12276-021-00678-9

Fig. 6. Conformational change in the hETA model structure induced by ET-1 binding.

Fig. 6

a Structures of ligand-free ETA (red) and ET-1-bound ETA (cyan). The structures are viewed from the outside of the cell (top view). b The structure as viewed from the side. The binding site of AG8 predicted by protein docking analysis is represented by a dotted circle. The numbers 1 through 7 in the yellow circles indicate the transmembrane domain of hETA.