Fig. 1.

The expression of miR-200b-3p was down-regulated in UC rats. A The expression of miR-200b-3p in each group was detected by qRT-PCR. (n = 10, ^* vs. Control; ^# vs. Model+agomiR-NC; ^{^} vs. Model+antagomiR-NC. ^{^}P < 0.05; ^***P < 0.001; ^###P < 0.001). B Effect of miR-200b-3p on disease activity index (DAI) in each group rats. (n = 10, ^* vs. Control; ^# vs. Model+agomiR-NC; ^{^} vs. Model+antagomiR-NC. ^{^^^}P < 0.001; ^***P < 0.001; ^###P < 0.001). C Colon weight/length ratio in each group rats. (n = 10, ^* vs. Control; ^# vs. Model+agomiR-NC; ^{^} vs. Model+antagomiR-NC. ^{^^}P < 0.01; ^***P < 0.001; ^##P < 0.01). D H&E staining identified the effect of miR-200b-3p on the pathological status of colon in each group rats. E and F ELISA was used to detect the effect of miR-200b-3p on the expressions of related inflammatory factors in each group rats. (n = 10, ^* vs. Control; ^# vs. Model+agomiR-NC; ^{^} vs. Model+antagomiR-NC. ^{^^}P < 0.01; ^{^^^}P < 0.001; ^***P < 0.001; ^##P < 0.01; ^###P < 0.001). Group: Control group; Model group; Model+agomiR-NC group; Model+agomiR group; Model+antagomiR-NC group; Model+antagomiR group. qRT-PCR quantitative reverse transcription polymerase chain reaction, H&E hematoxylin and eosin staing, ELISA enzyme-linked immuno sorbent assay, TGF-β transforming growth factor beta, IL-10 interleukin 10, CRP, C-reactive protein