Table 1.
Pantoprazole pharmacokinetic parameters following a single intravenous (1 mg/kg) administration to adult goats.
| Compound | Parameter | Unit | Geomean | Median | Min | Max |
|---|---|---|---|---|---|---|
| Pantoprazole | C0 | μg/mL | 3.1 | 4.1 | 1.0 | 5.9 |
| AUClast | hr*μg/mL | 1.1 | 1.1 | 0.7 | 1.8 | |
| AUCinf | hr*μg/mL | 1.1 | 1.2 | 0.8 | 1.8 | |
| AUMCinf | hr2*μg/mL | 0.6 | 0.7 | 0.3 | 1.0 | |
| MRTINF | hr | 0.5 | 0.5 | 0.4 | 0.9 | |
| Cl | mL/kg/hr | 20.5 | 20.5 | 13.3 | 31.4 | |
| T1/2 (λz) | hr | 0.7 | 0.6 | 0.5 | 1.5 | |
| Vss | L/kg | 0.5 | 0.5 | 0.3 | 1.2 | |
| Vz | L/kg | 0.9 | 0.8 | 0.4 | 2.7 |
AUClast, Area under pantoprazole concentration–time curve from time zero to last measurement; AUCinf, Area under pantoprazole concentration–time curve from time zero to infinity; AUMCinf, the area under the first-moment curve from time zero to infinity; MRTinf, Mean residence time extrapolated to infinity; Cl, Plasma clearance; T1/2 (λz), Elimination half-life; C0, Maximum concentration extrapolated to time zero; Cmax, Maximum concentration; Vz, Volume of distribution (terminal phase); Vss, Volume of distribution at steady-state.