Table 2.

Pantoprazole sulfone pharmacokinetic parameters following a single intravenous (1 mg/kg) administration of pantoprazole sodium to adult goats.

Compound	Parameter	Unit	Geomean	Median	Min	Max
Pantoprazole	Cmax	μg/mL	0.1	0.2	0.04	0.4
Sulfone	Tmax	hr	0.5	0.5	0.3	0.8
	AUClast	hr*μg/mL	0.2	0.2	0.1	0.6
	AUCinf	hr*μg/mL	0.2	0.2	0.1	0.7
	AUMCinf	hr2*μg/mL	0.3	0.3	0.1	0.9
	T1/2 (λz)	hr	0.8	0.9	0.5	1.0
	MRTINF	hr	1.3	1.4	1.1	1.6

Cmax, Maximum concentration; Tmax, Time to maximum concentration; AUClast, Area under pantoprazole concentration–time curve from time zero to last measurement; AUCinf, Area under pantoprazole concentration–time curve from time zero to infinity; AUMCinf, the area under the first-moment curve from time zero to infinity; T1/2 (λz), Elimination half-life; MRTinf, Mean residence time extrapolated to infinity.