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. 2021 Sep 22;12:666594. doi: 10.3389/fimmu.2021.666594

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Copyright © 2021 Gao, Yue and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ABD-VP1-induced local immune responses in the dLNs. (A) Schematic diagram of the immunization procedure. (B) FACS analysis of DC recruitment and maturation in the dLNs of immunized mice. (C) Statistical analysis of (B). (D) Mean fluorescence intensity (MFI) of MHC II, CD86 or CD80 molecule on CD11c⁺ DC in the dLNs. (E) FACS analysis of IFN-γ⁺ CD8⁺ and IFN-γ⁺ CD4⁺ cells in the dLNs (unstimulated background has been subtracted). (F) Statistical analysis of (E). Each group contained 8 mice. *P < 0.05; **P < 0.01; ***P < 0.001.