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ABD-VP1-induced splenic T cell immune responses. (A) CVB3-specific T cell proliferation in the spleens of immunized mice. (B) CVB3-specific CTL activity in the spleens. (C) Percentages of IFN-γ+ CD8+ and IFN-γ+ CD4+ cells in the spleens (unstimulated background has been subtracted). (D) Statistical analysis of (C). (E) Levels of serum neutralizing antibody in immunized mice. Each group contained 6 mice. *P < 0.05; **P < 0.01; ***P < 0.001.
