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. 2021 Sep 22;12:666594. doi: 10.3389/fimmu.2021.666594

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Copyright © 2021 Gao, Yue and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enhanced immunoprotection against viral myocarditis induced by ABD-VP1 vaccine. Mice were challenged with 3LD₅₀ CVB3 2 weeks post the final immunization, and myocarditis severity was evaluated 7 days later by (A) body weight loss, (B) cardiac function and (C) histomorphological changes of heart tissues. (D) Statistical analysis of (C). (E) Meanwhile, viral loads in the hearts were also detected. (F) A 28-day survival rate was observed after 5LD₅₀ CVB3 infection. *P < 0.05 for VP1 versus ABD-VP1. Each group contained 8 mice. For histomorphological observation, each group contained 6 mice. For survival rate evaluation, each group contained 15 mice. *P < 0.05; **P < 0.01; ***P < 0.001.