TABLE 1.

siRNA therapeutic applications in clinical trials.

Name	Disease	Target	ClinicalTrials.gov Identifier	Recruitment Status	Phase	Reference
Inclisiran	Homozygous Familial Hypercholesterolemia	PCSK9	NCT02597127	Completed	II	Ray et al. (2017)
			NCT03397121	Completed	III	Raal et al. (2020)
AGN211745	CNV-AMD	VEGFR1	NCT00363714	Completed	I & II	Kaiser et al. (2010)
PF-04523655	CNV-AMD	VEGFR1	NCT00713518	Completed	II	Nguyen et al. (2012a)
PF-04523655	Diabetic Macular Edema	RTP801	NCT00701181	Terminated	II	Nguyen et al. (2012b)
QPI-1007	Non-Arteritic Anterior Ischemic Optic Neuropathy	Caspase 2	NCT01064505	Completed	I	Antoszyk et al. (2013)
siG12D LODER	Pancreatic Cancer	KRASG12D	NCT01188785	Completed	I	Golan et al. (2015)
			NCT01676259	Unknown	II	Varghese et al. (2020)
TKM-080301	Hepatocellular Carcinoma	PLK1	NCT02191878	Completed	I/II	El Dika et al. (2019)
	Solid Cancer		NCT01262235	Completed	I/II	Demeure et al. (2016)
Atu027	Advanced Solid Tumors	Protein kinase N3	NCT00938574	Completed	I	Schultheis et al. (2014)
	Pancreatic Cancer		NCT01808638	Completed	I/II	Schultheis et al. (2016)
DCR-MYC	Solid Tumors, Multiple Myeloma, or Lymphoma	MYC	NCT02110563	Terminated	I	Tolcher et al. (2015)
CALAA-01	Solid Tumor	RRM2	NCT00689065	Terminated	I	Davis et al. (2010)
TD101	Pachyonychia congenita	KRT6A	NCT00716014	Completed	I	Leachman et al. (2010)
ARC-520	Healthy	cccDNA-derived viral mRNA	NCT01872065	Completed	I	Schluep et al. (2017)
	Chronic Hepatitis B		NCT02452528	Terminated	II	Yuen et al. (2020)
QPI-1002	Acute Renal Failure	p53	NCT00554359	Completed	I	Demirjian et al. (2017)
	Acute kidney injury		NCT00802347	Completed	I/II	Peddi et al. (2014)