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. 2021 Sep 22;12:729186. doi: 10.3389/fimmu.2021.729186

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Copyright © 2021 Fischinger, Cizmeci, Shin, Davies, Grace, Sivro, Yende-Zuma, Streeck, Fortune, Lauffenburger, Naidoo and Alter

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mtb-specific antibody profile across recurrent/no recurrent TB patient cohort. (A) The annotated heatmap shows antibody measurements across time, groups and displays demographic data. The first row of the heatmap delivers information of grouping into individuals who go on to get recurrent TB (orange) versus who do not get recurrent TB (grey). Days to TB recurrence for the recurrence group is indicated in shades of orange, days from cure are colored in grey for all individuals. The row below in blue shades reveals if participants had (1) or did not (2) have previous TB before enrollment into the parent study. Age, gender, CD4 levels and viral load are indicated. Antibody effector functions, titer and Fc-receptor binding are displayed, antigens for the functions are PPD, EDAT6/CFP10 and LAM, additional antigens for titer and Fc-receptor binding include Hspx, Ag85, RV0826 and RV1363, in this order. (B) IgG1 and IgG3 titers are shown over time for the recurrent TB group (top) and the no recurrence group (bottom) for PPD, ESAT6/CFP10, LAM and Hspx. X axis depicts time since TB cure1 at enrollment into the study and color in the recurrence group represents time to TB recurrence in shades of orange.