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. 2021 Sep 22;12:729186. doi: 10.3389/fimmu.2021.729186

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Copyright © 2021 Fischinger, Cizmeci, Shin, Davies, Grace, Sivro, Yende-Zuma, Streeck, Fortune, Lauffenburger, Naidoo and Alter

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Individuals who do not get recurrent TB have higher titers of IgG3. All graphs show data for the most distant time point from time since cure. (A) Nightingale rose charts allow for comparison between groups for antibody titer (IgG1-IgG4, IgA, IgM), Fc-receptor binding levels (FCR2A, 2B, 3A, 3B) and the ability to induce effector functions (ADCP, ADNP) at the most distant time point from TB cure1. The left column shows flowers for the recurrent TB group, the right side for the no recurrence group. Relative responses for PPD (top), ESAT6/CFP10 (middle) and LAM (bottom) are shown. (B) Dot plots show univariate IgG3 levels (MFI) across different Mtb antigens, median is indicated by line. For Hspx, IgG3:IgG2 ratios are depicted additionally. Grey depicts no recurrence, orange recurrent TB. Each dot represents the average within each matching bin. P-values were calculated using Wilcoxon signed-rank test and adjusted for multiple comparison using Benjamini-Hochberg method.