Fig. 5.

The effect of m6A RNA methylation regulators, the risk score and clinicopathological variables on the prognosis of HCC. (A) Cox univariate analysis of m6A RNA methylation regulators; (B) Partial likelihood deviance versus log (λ) was drawn using LASSO Cox regression model; (C) Coefficients of selected features are shown by lambda parameter. (D) The Kaplan–Meier OS curves for HCC patients assigned to high- and low-risk groups based on the risk score; (E) Time‑dependent risk receiver operating characteristic curves. The 1‑, 3‑ and 5‑year risk AUC were 0.765, 0.722 and 0.619, respectively; (F) The heatmap shows the expression of 5 m6A RNA methylation regulators and the distribution of clinicopathological variables between the high- and low-risk groups (red is upregulated and green is downregulated; *P < 0.05, **P < 0.01); (G) Forest plot of univariate Cox regression analysis in HCC; (H) Forest plot of multivariate Cox regression analysis in HCC.