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. 2021 Sep 22;12:753153. doi: 10.3389/fphar.2021.753153

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Copyright © 2021 Hwang, Wang, Lee, Lee, Choi, Choi and Son.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Yeokwisan on the level of ghrelin in plasma, and ghrelin-related genes in stomach and small intestine tissues. The level of acyl-ghrelin in plasma was determined using ELISA (A). mRNA expression analyses of ghrelin in stomach tissue (B) and ghrelin-associated genes in the stomach (C) and small intestine (D) were performed. The Yeokwisan group was treated with a dose of 400 mg/kg in (B–F). The data are presented as the mean ± SEM. ##p < 0.01 compared with the normal group; *p < 0.05, **p < 0.01 compared with the control group. GHSR, growth hormone secretagogue receptor; GOAT, ghrelin-O-acyltransferase; ADRB1, adrenergic receptor β1; SSTR, somatostatin receptor.