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. 2021 Sep 22;12:724037. doi: 10.3389/fgene.2021.724037

Table 5.

Runtime (CPU time) in hours and as factors for imputation and phasing.

Tools Runtime in hours Runtime as factors
Imputation Phasing Imputation Phasing
Beagle5.1 5.81 3.50 2.18 1
Beagle4.1 31.65 11.85
Eagle2.4.1* 4.47 1.28
Eagle2.4.1 4.68 1.33
IMPUTE2 34.57 12.95
IMPUTE4 32.73 12.26
minimac3 57.29 21.46
minimac4 48.69 18.24
PBWT 2.67 1
SHAPEIT2 14.07 4.02
SHAPEIT2* 24.20 6.91

For the factors, the fastest tool within imputation and phasing programs was chosen as factor one. For this table, the gain of speed due to parallelization is disregarded, since it is highly dependent on the local machines and chunking. Intel Xeon E5-2680 CPUs were used for phasing and imputation. Phasing tools marked with an asterix indicate the use of a reference panel for phasing.