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. 2021 Sep 22;12:671152. doi: 10.3389/fphar.2021.671152

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Copyright © 2021 Fu, Xiao, Tian, Liu, Xu, Yang, Hu, Zhou, Fang, Gao, Zhang, Mu, Zhang, Hu, Huang, Chen and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JY5 significantly alleviates hepatic inflammatory injury and collagen deposition in CCl₄-induced mouse liver fibrosis. (A) H&E staining (100×), SR staining (100×) and Masson staining (100×) in liver tissue. Serum levels of ALT (B) and AST (C) were measured in each group. (D) Semi-quantitative analysis of collagen disposition (%) in SR-stained liver sections. (E) Hyp content in wet liver tissue was detected by alkaline hydrolysis. (F) The mRNA expression of Col-I in mice liver tissue was analyzed by qPCR. **p < 0.01, ***p < 0.001 vs the control group, ^# p < 0.05, ^## p < 0.01 vs the CCl₄ group. Oil: control group.