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. 2021 Sep 22;12:671152. doi: 10.3389/fphar.2021.671152

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Copyright © 2021 Fu, Xiao, Tian, Liu, Xu, Yang, Hu, Zhou, Fang, Gao, Zhang, Mu, Zhang, Hu, Huang, Chen and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JY5 inhibits the activation of HSCs in vivo. (A) In the CCl₄-induced rat liver fibrosis experiment, representative images of IHC (100×) staining for a-SMA and desmin. Quantitative analysis of immunohistochemical staining for a-SMA (B) and desmin. (C) The protein and mRNA levels of a-SMA were, respectively, analyzed by qPCR (D) and Western blotting (E). (F) In the CCl₄-induced liver fibrosis mice experiment, representative images of IHC (100×) staining for a-SMA and desmin in liver tissue from mice treated with the various treatments. Quantitative analysis of immunohistochemical staining for a-SMA (G) and desmin. (H) The protein and mRNA levels of a-SMA in mice liver tissue were, respectively, analyzed by qPCR (I) and Western blotting (J). (K) In the BDL-induced rat liver fibrosis experiment, representative images of IHC (100×) staining for a-SMA and desmin in liver tissue. Quantitative analysis of immunohistochemical staining for a-SMA (L)and desmin (M). The protein and mRNA expression of a-SMA was, respectively, analyzed by qPCR (N) and Western blotting (O). **p < 0.01, ***p < 0.001 vs the control group or sham group, ^# p < 0.05, ^## p < 0.01 vs the CCl₄ group or BDL group. Oil: control group.