Figure 5.

The genomic landscape of liver hepatocellular carcinoma and mutational signatures. Top panel shows individual tumor mutation rates, while the middle panel details ethnicity, tumor grade, age, gender, HCV, and HBV infection status, and cirrhosis for 363 patients with HCC. Bottom panel shows genes with significantly different levels of mutation (MutSig suite, FDR, <0.1), and mutation types are indicated in the legend, at the bottom. The bottom six rows display significant DNA copy number alterations in likely cancer driver genes.

Abbreviations: HCV, hepatitis C virus; HBV, hepatitis B virus; HCC, hepatocellular carcinoma.