Table 3.
Five activity phenotypes of clopidogrel metabolic responses.
| Metabolizer Phenotype | Genotype with Examples | Frequency | Antiplatelet Response |
|---|---|---|---|
| Poor | 2 LOF alleles(*2*2, *2/*3, *3/*3) | 1%–5%Highest in Asia: 12.2% | Effectively absent |
| Intermediate | 1 LOF/NF allele (*1/*2, *1/*3, *2/*17, *3/*17) | 20%–30%Highest in Asia: 45.5% | Reduced |
| Normal | 2 NF alleles (*1/*1) | 35%–50% | Normal |
| Rapid | 1 GOF allele (*1/*17) | 20%–30%Highest in Middle East: 32% | Normal to increased |
| Ultrarapid | 2 GOF alleles (*17/*17) | 1%–5%Highest in Americas: 4.2% | Normal to increased |
LOF/NF = Loss of/No Function; GOF = Gain of Function; NF = Normal Function.