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Expression of ABCC3 and chemoresistance. ABCC3 can be positively regulated by different transcription factors targeted by antineoplastic drugs. ABCC3 contributes to chemoresistance by increasing the export of antineoplastic drugs outside the cells, which ultimately leads to cancer progression. PXR: pregnane X receptor, Nrf2: nuclear factor erythroid 2-related factor 2, YB-1: Y-box binding protein-1.
