Table 1.
Univariate and multivariate analyses of DFS and OS based on clinic-pathological factors in patients with HGNECC at early-stage
| N | DFS | N | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
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| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||
|
|
|
|
|
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| HR (95%) | P | HR (95%) | P | HR (95%) | P | HR (95%) | P | |||
| Stage | ||||||||||
| IB | 87 | 0.863 (0.447-1.663) | 0.659 | 91 | 0.89 (0.619-1.280) | 0.530 | ||||
| IIA | 18 | Reference | 18 | Reference | ||||||
| Age | ||||||||||
| <40 | 42 | 0.979 (0.577-1.658) | 0.936 | 43 | 1.013 (0.757-1.356) | 0.929 | ||||
| ≥.9 | 63 | Reference | 66 | Reference | ||||||
| Tumor size | ||||||||||
| ≤ umo | 69 | 0.308 (0.183-0.518) | 0.000 | 0.350 (0.206-0.594) | 0.000 | 70 | 0.421 (0.237-0.750) | 0.003 | 0.413 (0.227-0.751) | 0.004 |
| >4 cm | 36 | Reference | Reference | 39 | Reference | Reference | ||||
| Histological heterogeneity | ||||||||||
| Pure | 85 | 1.000 (0.518-1.928) | 1.000 | 89 | 0.896 (0.632-1.271) | 0.539 | ||||
| Mix | 20 | Reference | 20 | Reference | ||||||
| Parametrium invasion | ||||||||||
| No | 98 | 0.777 (0.310-1.944) | 0.589 | 102 | 1.253 (0.617-2.547) | 0.532 | ||||
| Yes | 7 | Reference | 7 | Reference | ||||||
| Deep cervical stromal invasion | ||||||||||
| No | 30 | 0.490 (0.254-0.946) | 0.034 | 0.864 (0.418-1.785) | 0.692 | 32 | 0.535 (0.259-1.108) | 0.092 | 0.629 (0.299-1.321) | 0.221 |
| Yes | 75 | Reference | Reference | 77 | Reference | Reference | ||||
| LVSI | ||||||||||
| No | 39 | 0.367 (0.197-0.683) | 0.002 | 0.434 (0.231-0.816) | 0.009 | 41 | 0.431 (0.223-0.833) | 0.012 | 0.750 (0.346-1.625) | 0.466 |
| Yes | 66 | Reference | Reference | 68 | Reference | Reference | ||||
| LNM | ||||||||||
| No | 66 | 0.544 (0.324-0.912) | 0.021 | 0.794 (0.456-1.382) | 0.415 | 68 | 0.456 (0.257-0.809) | 0.007 | 0.538 (0.297-0.978) | 0.042 |
| Yes | 39 | Reference | Reference | 41 | Reference | Reference | ||||
| Ovary preserved | ||||||||||
| No | 75 | 0.855 (0.494-1.482) | 0.577 | 78 | 0.762 (0.569-1.020) | 0.068 | 0.769 (0.568-1.042) | 0.090 | ||
| Yes | 30 | Reference | 31 | Reference | Reference | |||||
| NAC | ||||||||||
| No | 83 | 0.491 (0.281-0.859) | 0.013 | 0.837 (0.455-1.540) | 0.567 | 86 | 0.426 (0.229-0.792) | 0.007 | 0.733 (0.357-1.506) | 0.398 |
| Yes | 22 | Reference | Reference | 23 | Reference | Reference | ||||
| CT cycle | ||||||||||
| <5 | 63 | 0.967 (0.745-1.254) | 0.799 | 65 | 1.021 (0.763-1.366) | 0.890 | ||||
| ≥5 | 42 | Reference | 44 | Reference | ||||||
| CT reagements | 0.451 | 0.813 | ||||||||
| EP | 59 | 0.772 (0.274-2.172) | 0.524 | 63 | 0.772 (0.235-2.542) | 0.671 | ||||
| TP | 24 | 0.577 (0.185-1.797) | 0.343 | 24 | 0.759 (0.212-2.722) | 0.672 | ||||
| TC | 11 | 0.382 (0.095-1.534) | 0.175 | 11 | 0.621 (0.139-2.781) | 0.533 | ||||
| EC | 5 | 0.349 (0.064-1.910) | 0.225 | 5 | 0.255 (0.026-2.455) | 0.237 | ||||
| others | 6 | Reference | 6 | Reference | ||||||
| Pre-operative RT | ||||||||||
| No | 103 | 0.307 (0.074-1.267) | 0.102 | 107 | 0.418 (0.203-0.859) | 0.018 | 0.412 (0.198-0.859) | 0.018 | ||
| yes | 2 | Reference | 2 | Reference | Reference | |||||
| Post-operative RT | ||||||||||
| No | 48 | 0.798 (0.471-1.351) | 0.401 | 48 | 1.096 (0.822-1.462) | 0.531 | ||||
| Yes | 58 | Reference | 61 | Reference | ||||||