Trends in (A) mean body mass index (calculated as weight in kilograms divided by height in meters squared) (all P < .001 for linear trend); (B) mean systolic blood pressure (P = .001 for linear trend, P < .001 for nonlinear trend, P = .003 for nonlinear trend, and P = .002 for nonlinear trend in Asian, Black, Hispanic, and White individuals, respectively); (C) mean hemoglobin A1c (P = .26 for trend in Asian individuals; for all others, P < .001 for linear trend); (D) mean serum total cholesterol (to convert to millimoles per liter, multiply by 0.0259) (P = .76 for linear trend in Asian individuals; for all others, P < .001 for linear trend); (E) prevalence of current cigarette smoking (P > .05 for trend in Asian and Black individuals; P < .001 for linear trend in Hispanic and White individuals); and (F) mean estimated 10-year risk of atherosclerotic cardiovascular disease (ASCVD) (P = .26 for trend, P = .03 for nonlinear trend, P = .02 for linear trend, and P < .001 for linear trend in Asian, Black, Hispanic, and White individuals, respectively). The 10-year risk of ASCVD was calculated using the Pooled Cohort Equations among individuals without a self-reported history of cardiovascular disease. The probability of developing ASCVD over 10 years ranged from 0% to 100%. All estimates were standardized to the 2000 US Census population using 6 age and sex categories: men aged 20-39, 40-59, and ≥60 years and women aged 20-39, 40-59, and ≥60 years. Linear and polynomial models were used to test linear and nonlinear trends. The homogeneity of trends among racial and ethnic subgroups was tested using an interaction term of time × race and ethnicity in the regression models. Error bars indicate 95% CIs.