Table 4.

Effect of ATRA treatment on T cell production of 27 Innate Cytokines, under differing stimulation combinations (Unstimulated and anti-CD3CD28 beads), measured by Luminex. Data analysed by Mixed Model, LS means and Type III decomposition using Statistica (Quest Software, Elliot Management Group). A p-value less than 0.05 was considered significant.

Analytes	T cell treated with ATRA vs T cell untreated
	Unstim (p-value)	Significant Increase/Decrease/ns	aCD3CD28 (p-value)	Significant Increase/Decrease/ns
IL1b	0.93224	ns	0.980514	ns
IL1ra	0.607315	ns	0.664356	ns
IL2	0.907946	ns	0.476152	ns
IL4	0.808789	ns	0.000012	increase
IL6	0.418197	ns	0.404916	ns
IL7	0.060996	ns	0.233229	ns
IL9	0.513908	ns	0.000004	decrease
IL10	0.733901	ns	0.029443	decrease
IL12	0.000029	decrease	0.175689	ns
IL13	0.807077	ns	0.070138	ns
IL15	0.398862	ns	0.838695	ns
IL17A	0.802545	ns	0.001726	decrease
FGF basic	0.579758	ns	0.543935	ns
IFNg	0.953108	ns	0.272509	ns
MCP1	0.024316	increase	0.789536	ns
MIP1a	0.996559	ns	0.000029	decrease
PDGF-bb	0.006977	increase	0.997963	ns
MIP1b	0.753384	ns	0.034838	decrease
TNFa	0.302195	ns	0.010654	decrease
IL5	0.718635	ns	0.148093	ns
IL8	0.056845	ns	0.333874	ns
Eotaxin	0.373247	ns	0.626624	ns
G-CSF	0.907528	ns	0.266079	ns
IP10	0.023365	decrease	0.053419	ns
RANTES	0.166528	ns	0.16034	ns
GM-CSF	0.957072	ns	0.011559	decrease
VEGF	0.758214	ns	0.001114	decrease