Scheme 1:
Preparation of building block aminopyrazoles 4.
Conditions: (a) MeCN, n-BuLi, THF, −78 °C to rt; (b) R1NH-NH2, MeOH, 120 °C, microwave or R1NH-NH2·HCl, NEt3, MeOH, 120 °C, microwave.
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