Figure 9.

Scatter plots of cryptococcal selectivity, biochemical potency, and whole cell activity for Table 4 RAPs, binned by aminopyrazole substructure class as defined by the R¹ and R² substitution patterns. The Y-axis depicts cryptococcal fold-selectivity on a logarithmic scale. Points are colored by H99 lysate EC₅₀ on a logarithmic scale, on a gradient ranging from cyan (10 μM) to red (1 nM). Point symbols indicate whole cell activity class, with circles corresponding to compounds with little to no whole cell activity (H99 MIC ≥25 μM), and stars indicating whole cell active compounds with a H99 MIC <25 μM.