Figure 5 .

Significant correlations between GM volume loss of different BF cholinergic compartments and atrophy of their innervated regions in T+ (A), preclinical AD (B), and prodromal AD (C, D). Results were corrected for multiple comparisons (FWE, P < 0.05). L, left; R, right. Note that tauopathy (T+) is a requirement for the emergence of the structural coupling between Ch4 and amygdala (A), the spatial extent of this coupling being larger in preclinical/prodromal AD than in T+ (B, C). The structural coupling between Ch1–Ch2 and hippocampus only occurred in prodromal AD (D).