Table 2.

Extent of atrophy of BF cholinergic compartments, amygdala, and hippocampus in T+, preclinical AD (A+T+), and prodromal AD (A+T+) compared with controls (A−T−)

Brain region	CS (mm3)	P	x	y	z	T
Control > T+
Basal forebrain
Right Ch4	91	10−3	20	-4	−10	4.7	0.72
Left Ch4	33	10−2	−19	−5	−12	3.8	0.76
Amygdala
Right amygdala	136	10−3	15	−2	−18	5.1	0.23
Right amygdala	39	10−2	22	5	−21	5.4	0.15
Left amygdala	17	10−2	−19	−5	−13	3.9	0.18
Control > preclinical AD
Basal forebrain
Right Ch1–Ch2	24	10−2	3	2	−9	3.8	0.16
Left Ch4	161	10−4	−23	−4	−12	7.3	0.66
Right Ch4	181	10−4	24	−4	−12	7.1	0.65
Amygdala
Left amygdala	1457	10−6	−23	−4	−13	7.9	0.28
Right amygdala	1870	10−7	25	−6	−12	7.8	0.26
Hippocampus
Left hippocampus	238	10−4	−21	−12	−18	6.5	0.36
Right hippocampus	231	10−4	15	−9	−16	6.6	0.35
Right hippocampus	52	10−3	21	−35	−1	5.4	0.35
Control > prodromal AD
Basal forebrain
Right Ch1–Ch2	201	10−3	0	6	−8	5.5	0.47
Right Ch1–Ch2	22	10−2	8	3	−14	4.4	0.31
Left Ch4	273	10−5	−22	−6	−11	10.9	0.78
Right Ch4	181	10−4	20	−7	−12	8.3	0.72
Amygdala
Left amygdala	2616	10−8	−22	−6	−12	12.1	0.41
Right amygdala	2115	10−7	25	−6	−15	9.2	0.26
Hippocampus
Left hippocampus	2156	10−13	19	−9	−16	8.4	0.36
Right hippocampus	2638	10−14	−22	−10	−20	8.3	0.35

Note: CS, cluster size (>5 voxels), it refers to the extent of atrophy; P, cluster-level FWE correction (P < 0.05), peak MNI coordinates (x-y-z); T, peak t-value; , peak partial eta-squared showing the effect size.