Table 2.

Functional enrichment results of PBMC RNA-seq data of the interictal vs. healthy comparison. DE list enrichment: overrepresentation of functional terms in the differentially expressed gene list. Ranked list enrichment: enrichment of genes associated with a certain pathway towards the top of the ranked whole data. GO: gene ontology, BP: biological process, CC: cellular component, MF molecular function. KEGG: Kyoto Encyclopedia of Genes and Genomes. Annotated: number of genes associated with the given term. R: Reactome database. Significant: number of statistically significant associated with the given term. Expected: expected number of genes associated with the given term in the DE gene list. Gene ratio: ratio of number of genes in the DE list that overlap with genes associated with the given term, and the number of genes in the DE list which overlap with genes associated with all terms in the Reactome database. Bg ratio: ratio of the number of genes associated with the given term, and the total number of genes associated with Reactome terms

Interictal vs. healthy
ID	DE list enrichment	Annotated	Significant	Expected	p-value
GO:0006954 BP	inflammatory response	625	31	6.03	2.60E-14
GO:0005126 MF	cytokine receptor binding	210	14	1.89	6.10E-09
GO:0042379 MF	chemokine receptor binding	37	6	0.33	8.90E-07
		GeneRatio	BgRatio		p-value
R-HSA-6783783	Interleukin-10 signaling	11/96	40/8821		2.60E-14
	Ranked list enrichment	Annotated			p-value
GO:0022900 BP	electron transport chain	173			2.60E-14
GO:0005746 CC	mitochondrial respiratory chain	82			2.17E-05
GO:0016684 MF	oxidoreductase activity, acting on peroxide as acceptor	50			0.000016
KEGG 190	Oxidative phosphorylation	121			8.82E-06
KEGG 4080	Neuroactive ligand-receptor interaction	157			2.28E-05