Table 3.

Functional enrichment results of PBMC RNA-seq data of the ictal vs. interictal comparison. DE list enrichment: overrepresentation of functional terms in the differentially expressed gene list. Ranked list enrichment: enrichment of genes associated with a certain pathway towards the top of the ranked whole data. GO: gene ontology, BP: biological process, CC: cellular component, MF molecular function. KEGG: Kyoto Encyclopedia of Genes and Genomes. Annotated: number of genes associated with the given term. R: Reactome database. Significant: number of statistically significant associated with the given term. Expected: expected number of genes associated with the given term in the DE gene list. Gene ratio: ratio of number of genes in the DE list that overlap with genes associated with the given term, and the number of genes in the DE list which overlap with genes associated with all terms in the Reactome database. Bg ratio: ratio of the number of genes associated with the given term, and the total number of genes associated with Reactome terms

Ictal vs. interictal
ID	DE list enrichment	Annotated	Significant	Expected	p-value
GO:1902305 BP	regulation of sodium ion transmembrane transport	55	4	0.39	2.60E-14
GO:0070382 CC	exocytic vesicle	175	6	1.3	0.0019
GO:0005179	hormone activity	61	3	0.43	0.00924
KEGG 4742	Taste transduction	35	2	0.219161	0.019843
	Ranked list enrichment	Annotated			p-value
GO:0005746 CC	mitochondrial respiratory chain	82			2.60E-14
GO:0005125 MF	cytokine activity	149			0.000001
GO:0005179 MF	hormone activity	61			6.95E-05
GO:0030594 MF	neurotransmitter receptor activity	57			0.000107
GO:0004984 MF	olfactory receptor activity	44			0.000433
KEGG 4080	Neuroactive ligand-receptor interaction	157			9.04E-05
KEGG 190	Oxidative phosphorylation	121			0.000845
KEGG 140	Steroid hormone biosynthesis	36			0.00112