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Schematic diagram describing the functional significance of HOTAIRM1 in NPM1-mutated leukemia cells. HOTAIRM1 expression was induced by mutant NPM1 via KLF5-dependent transcriptional regulation. Nuclear HOTAIRM1 promoted EGR1 degradation by enhancing the MDM2-EGR1 interaction, while cytoplasmic HOTAIRM1 increased ULK3 expression by competitively sponging miR-152-3p, therefore contributing to autophagy and proliferation in NPM1-mutated AML cells
