Table 2.
Clinical characteristics of patients according to the presence/absence of END and HT after IVT treatment.
| Variables |
Total
(n = 581) |
No END
(n = 531) |
END (n = 50) | P |
No HT
(n = 499) |
HT
(n = 82) |
P |
|---|---|---|---|---|---|---|---|
| Age, years, median (IQR) | 61 (53-69) | 62 (53-69) | 59.5 (53.5-67.5) | 0.448 | 62 (54-70) | 57 (50.75-66) | 0.006 |
| Sex (male), n (%) | 423 (72.8) | 385 (72.5) | 38 (76) | 0.595 | 358 (71.7) | 65 (79.3) | 0.156 |
| Current smoking, n (%) | 326 (56.1) | 300 (56.5) | 26 (52) | 0.54 | 277 (55.5) | 49 (59.8) | 0.473 |
| Current drinking, n (%) | 253 (43.5) | 235 (44.3) | 18 (36) | 0.26 | 212 (42.5) | 41 (50) | 0.203 |
| Atrial fibrillation, n (%) | 27 (4.6) | 27 (5.1) | 0 | 0.102 | 16 (3.2) | 11 (13.4) | <0.01 |
| Coronary artery disease, n (%) | 116 (20) | 107 (20.2) | 9 (18) | 0.716 | 103 (20.6) | 13 (15.9) | 0.315 |
| Diabetes, n (%) | 189 (32.5) | 167 (31.5) | 22 (44) | 0.07 | 153 (30.7) | 36 (43.9) | 0.018 |
| Hypertension, n (%) | 302 (52) | 271 (51) | 31 (62) | 0.138 | 260 (52.1) | 42 (51.2) | 0.882 |
| Time from stroke onset to IVT infusion (min), median (IQR) | 180 (141-230) | 180 (141-230) | 177.5 (150-225) | 0.992 | 179 (138-227) | 203 (153.75-236.25) | 0.109 |
| Prior stroke, n (%) | 88 (15.1) | 81 (15.3) | 7 (14) | 0.813 | 75 (15) | 13 (15.9) | 0.847 |
| Systolic blood pressure, mmHg, median (IQR) | 154 (138-165) | 154 (138-165) | 156.5 (144.25-167.25) | 0.271 | 154 (138-165) | 154 (139.5-165) | 0.910 |
| Diastolic blood pressure, mmHg, median (IQR) | 89 (80-98) | 89 (80-98) | 89.5 (80-98) | 0.988 | 89 (80-98) | 89 (82-98) | 0.390 |
| Antihypertensive therapy, n (%) | 200 (34.4) | 183 (34.5) | 17 (34) | 0.947 | 172 (34.5) | 28 (34.1) | 0.955 |
| Antiplatelet therapy, n (%) | 73 (12.6) | 62 (11.7) | 11 (22) | 0.035 | 56 (11.2) | 17 (20.7) | 0.016 |
| Hypoglycemic therapy, n (%) | 102 (17.6) | 89 (16.8) | 13 (26) | 0.101 | 83 (16.6) | 19 (23.2) | 0.149 |
| Baseline blood glucose, mmol/L, median (IQR) | 6.92 (6.13-8.65) | 6.92 (6.14-8.65) | 7.03 (5.97-9.06) | 0.815 | 6.92 (6.09-8.62) | 6.91 (6.18-9.56) | 0.444 |
| Baseline NIHSS score, median (IQR) | 9 (5-13) | 9 (5-13) | 6 (3-10) | <0.01 | 8 (5-12) | 12 (8-15) | <0.01 |
| Baseline neutrophil (109/L), median (IQR) | 5.41 (3.98-7.44) | 5.38 (3.95-7.38) | 5.65 (4.33-7.74) | 0.194 | 5.38 (3.94-7.17) | 6.17 (4.22-8.39) | 0.038 |
| Baseline PLT (109/L), median (IQR) | 200 (170-231) | 198 (168-230) | 213 (191.25-243.25) | 0.025 | 201 (170-231) | 192.5 (169.5-234) | 0.532 |
| Baseline PNR, median (IQR) | 36.71 (26.04-51.29) | 36.7 (26.09-51.46) | 37.73 (24.41-51.33) | 0.949 | 37.19 (26.59-52.61) | 32.47 (23.80-42.32) | 0.011 |
| Post-IVT neutrophil (109/L), median (IQR) | 5.39 (4.23-7.26) | 5.29 (4.16-7.07) | 7.17 (5.20-9.84) | <0.01 | 5.27 (4.13-7.06) | 6.3 (4.84-8.90) | <0.01 |
| Post-IVT PLT (109/L), median (IQR) | 205 (173-237) | 204 (172-237) | 219.5 (191-249.25) | 0.068 | 205 (173-238) | 204.5 (174.5-237.25) | 0.86 |
| Post-IVT PNR, median (IQR) | 37.76 (27.16-49.33) | 38.06 (27.88-50.11) | 29.92 (22.14-38.13) | 0.001 | 38.64 (28.42-50.93) | 30.73 (23.14-41.57) | <0.01 |
Abbreviations: END, Early Neurologic Deterioration; HT, Hemorrhagic Transformation; NIHSS, National Institute of Health Stroke Scale; PLT, Platelet; PNR, Platelet-to-Neutrophil Ratio; IVT, Intravenous Thrombolysis.