Table 2.

Box-Behnken design for formulation development of tobramycin sulphate loaded chitosan nanoparticles.

Run	X1(%)	X2(%)	X3(%)
1	-1 (0.03)	-1 (0.15)	0 (0.6)
2	-1 (0.07)	1 (0.15)	0 (0.6)
3	1 (0.03)	-1 (0.25)	0 (0.6)
4	1 (0.07)	1 (0.25)	0 (0.6)
5	-1 (0.03)	0 (0.2)	-1 (0.55)
6	-1 (0.07)	0 (0.2)	1 (0.55)
7	1 (0.03)	0 (0.2)	-1 (0.65)
8	1 (0.07)	0 (0.2)	1 (0.65)
9	0 (0.05)	-1 (0.15)	-1 (0.55)
10	0 (0.05)	-1 (0.25)	1 (0.55)
11	0 (0.05)	1 (0.15)	-1 (0.65)
12	0 (0.05)	1 (0.25)	1 (0.65)
13	0 (0.05)	0 (0.2)	0 (0.6)
14	0(0.05)	0 (0.2)	0(0.6)
15	0(0.05)	0 (0.2)	0(0.6)