TABLE 1.

Microbiological parameters of 37 penicillin-resistant pneumococcal isolates and clinical and demographic data for the patients

Patient			Pneumococcal strain
Age (yr)	Sex	Clinical diagnosisa	Centerb	Strain no.	Clinical originc	Penicillin MIC (μg/ml)	Resistance profiled	Serotype	BOX PCR type	RFEL typee (cluster)f	PBP genotype
<1	Female	URTI	7	39	Nose	4.0	PAXCDELT	23F	1	106 (I)	6-2-53
<1	Male	URTI	7	40	Nose	4.0	PAXCDELT	23F	1	106 (I)	6-1-53
Child	—g	URTI	6	32	Nose	4.0	PAXCDELT	23F	1	106 (I)	6-1-53
1	Male	URTI	7	26	Nose	4.0	PAXCDELT	23F	1	105 (I)	6-18-53
Child	Male	URTI	17	29	Nose	4.0	PAXCDELT	23F	1	105 (I)	6-18-56
1	Male	LRTI	1	6	Throat	8.0	PAXCDET	23F	1	105 (I)	16-3-1
<1	Male	LRTI	7	9	Blood	4.0	PAXCDELT	23F	1	105 (I)	6-18-53
1	Male	URTI	14	22	Nose	2.0	PAXCDELT	23F	1	145 (I)	6-14-43
6	Male	Otitis media	4	151	Ear	4.0	PA*CDE**	23F	1	44 (I)	6-14-43
4	Female	URTI	3	178	Nose	8.0	PA*CDE**	23F	1	44 (I)	6-14-1
4	Male	URTI	4	233	Throat	8.0	PA*CDE**	23F	1	45 (I)	6-14-1
5	Female	URTI	4	234	Throat	8.0	PA*CDE**	23F	1	45 (I)	6-14-1
Adult	Female	LRTI	2	4	Sputum	2.0	PAXCDET	23F	2	15 (II)	1-1-1
13	Female	LRTI	18	16	BAL	2.0	PAXDET	23F	2.1	15 (II)	1-1-1
3	Male	URTI	16	33	Throat	2.0	PAXCDET	23F	2	15 (II)	1-18-1
57	Male	Brain abscess	12	8	CSF	0.5	PCDELT	19A	3	104	7-17-52
55	Male	LRTI	10	2	BAL	1.0	PCT	6A	4	97	2-5-51
—	—	—	8	31	—	1.0	PD	Rough	5	148	0h-2-54
3	Female	URTI	7	36	Nose	1.0	PCDELT	6B	6	147	0-1-54
14	Male	LRTI	9	12	Sputum	0.12	PCDELT	6B	7	98 (III)	2-2-9
7	Male	LRTI	9	13	Sputum	0.12	PCDELT	6B	7	98 (III)	2-2-9
3	Female	LRTI	9	14	Blood	0.12	PCDELT	6B	7.1	98 (III)	2-2-9
1	Male	URTI	13	35	Nose	0.12	PCDELT	6B	7.2	98 (III)	2-18-9
6	Male	URTI	16	34	Nose	0.12	PCDELT	6B	7.1	98 (III)	2-18-9
Adult	—	LRTI	11	17	Sputum	0.12	PCDELT	6B	7.3	102 (III)	2-2-9
2	Male	URTI	14	23	Nose	0.12	PDE	6B	7.3	102 (III)	2-2-9
Child	Male	Conjunctivitis	2	30	Eye	0.12	PDEL	6B	7.1	102 (III)	2-2-9
12	Male	LRTI	9	15	Blood	0.12	PDEL	6B	7.2	101 (III)	2-2-9
<1	—	LRTI	2	5	Throat	0.12	PDEL	6B	7.3	99 (III)	2-2-9
5	Male	URTI	17	27	Nose	0.12	PCDET	6B	7.4	99 (III)	2-2-9
Child	Female	URTI	7	24	Nose	1.0	PACDT	9V	8	23 (IV)	1-1-1
Adult	Male	URTI	17	38	Nose	1.0	PAXCDET	9V	8.1	23 (IV)	1-2-1
Adult	Female	LRTI	6	1	Pleural fluid	1.0	PAXCDET	9V	8.1	23 (IV)	1-1-1
Child	Male	URTI	5	10	Nose	1.0	PAXCDET	9V	8	23 (IV)	1-5-1
Adult	—	LRTI	15	11	Sputum	2.0	PAXCDELT	14	8	23 (IV)	1-5-1
Child	Female	URTI	3	37	Throat	0.5	PXCDT	9V	8.1	23 (IV)	1-2-1
10	Female	URTI	19	181	Throat	1.0	PA*C**	9V	8.1	140 (IV)	1-1-1

^aURTI, upper respiratory tract infection; LRTI, lower respiratory tract infection. 

^bSee Fig. 1. 

^cBAL, broncheoalveolar lavage; CSF, cerebrospinal fluid. 

^dP, penicillin G; A, amoxicillin; X, cefotaxime, C, chloramphenicol; D, doxycycline; E, erythromycin; L, lincomycin; T, trimethoprim-sulfamethoxazole (co-trimoxazole); ∗, susceptibility to cefotaxime, lincomycin, and co-trimoxazole was not tested. 

^eThe arbitrary cutoff value for an identical RFEL type is 95%; RFEL codes refer exclusively to the genetic distances calculated by using the entire collection of 147 pneumococcal RFEL types, in which the Polish genotypes were included (see Materials and Methods) (13, 14). 

^fSee Fig. 2. 

^g—, data not available. 

^hUnknown PBP genotype.