Table 1. Top 30 gene signatures of each of incipient, subclinical, and clinical TB.
| Incipient versus control | Subclinical versus control | Clinical versus control |
|---|---|---|
| MTRNR2L10 a | MSLN | MTRNR2L10 a |
| C1QC b | CCDC144A | C1QC b |
| C1QB a | SPACA3 | MTRNR2L1 |
| CCL2 | HIST1H4A | C1QB a |
| HESX1 | HIST1H1B | ANKRD22 a |
| PCGF2 | HIST1H4F | SEPT4 |
| SERPING1 b | NXPH3 | SERPING1 b |
| LCN8 | HIST1H4B | BATF2 b |
| SEMA6B | ZBED6 | FAM20A |
| SIGLEC1 | HSPA12B | ETV7 b |
| C1QA a | TRAJ4 | EXOC3L4 |
| ISG15 | ETV7 b | PDCD1LG2 |
| AHRR | TAS2R3 | METTL7B |
| NEIL3 | HTRA1 | APOL4 |
| FBXO39 | BATF2 b | CFB |
| AXL | SERPING1 b | C1QA a |
| C2 a | GALNT4 | VWA3B |
| IFI6 | HIST2H2AB | SLC8A2 |
| LGALS2 | HIST1H1D | GBP6 a |
| IFITM3 | HIST1H1E | FCGR1A |
| RUFY4 | GBP6 a | C2 a |
| ETV7 b | HIST1H3C | CARD17 |
| TCN2 | SLC2A14 | EXOC3L1 a |
| LGALS3BP | TICAM2 | RHOV |
| EXOC3L1 a | GBP5 | AOC1 |
| COL23A1 | C1QC b | KCNMA1 |
| MT2A | TAS2R60 | FAM26F |
| BATF2 b | ANKRD22 a | KCNJ10 |
| CXCL10 | CH17-296N19.1 | CD274 |
| SCT | HIST1H4C | SDC3 |
Top 30 ranked genes selected by log2 fold change and FDR P = 0.05: 30 genes out of 47 coding DEGs in incipient TB; 30 genes out of 233 coding DEGs in subclinical TB; 30 genes out of 311 coding DEGs in clinical TB. No footnote: genes are unique to each of incipient, subclinical, and clinical top 30 genes expressed, although expressed in all datasets at lower levels.
a
Common in two out of three of the 30-gene signatures.
b
Common in all three 30-gene signatures.