Table 4.
Demographic and clinical exposures across fibrosis stages
| F0–F1 (n=114; 95%) | F2 (n=4; 3.3%) | F3 (n=2; 1.7%) | P value * | |
| Sex | NA | NA | NA | 0.97 |
| Female | 62 (54.4) | 2 (50) | 1 (50) | NA |
| Male | 52 (45.6) | 2 (50) | 1 (50) | NA |
| Parental education | NA | NA | NA | 0.43 |
| Lower than college | 9 (7.9) | 1 (25) | 0 | NA |
| College education | 105 (92.1) | 3 (75) | 2 (100) | NA |
| Residency | NA | NA | NA | 0.7 |
| Rural | 30 (26.3) | 1 (25) | 0 | NA |
| Urban | 84 (73.7) | 3 (75) | 2 (100) | NA |
| Smoker | NA | NA | NA | 0.37 |
| Yes | 8 (7) | 1 (25) | 0 | NA |
| No | 106 (93) | 3 (75) | 2 (100) | NA |
| Controlled attenuation parameter (dB/m) | 211 (198–258) | 229.5 (197–316.5) | 268.5 (225–312) | 0.2 |
| BMI, kg/m2 | 24.6 (19.7–30.5) | 27.1 (22.7–31.9) | 28.3 (27.2–29.4) | 0.22 |
| Underweight (<20 kg/m2) | 30 (26.3) | 1 (25) | 0 | 0.7 |
| Normal weight (20 to <25 kg/m2) | 30 (26.3) | 0 | 0 | 0.34 |
| Overweight (25 to <30 kg/m2) | 24 (21.1) | 2 (50) | 2 (100) | 0.014 |
| Obese (≥30 kg/m2) | 30 (26.3) | 1 (25) | 0 | 0.7 |
| Waist-to-height ratio | 0.48 (0.44–0.55) | 0.49 (0.46–0.57) | 0.54 (0.49–0.58) | 0.31 |
| First-degree history of diabetes | NA | NA | NA | 0.46 |
| Yes | 37 (32.5) | 2 (50) | 0 | NA |
| No | 77 (67.5) | 2 (50) | 2 (100) | NA |
| Fast food consumption | NA | NA | NA | 0.59 |
| Yes | 77 (67.5) | 3 (75) | 2 (100) | NA |
| No | 37 (32.5) | 1 (25) | 0 | NA |
| Exercise | NA | NA | NA | 0.048 |
| Yes | 37 (32.5) | 0 | 2 (100) | NA |
| No | 77 (67.5) | 4 (100) | 0 | NA |
| Alanine aminotransferase, IU/L | 15 (12–21) | 12.5 (10–18) | 20.5 (16–25) | 0.85 |
| Aspartate aminotransferase, IU/L |
21 (18–25) | 20.5 (16.5–25.5) | 23.5 (23–24) | 0.88 |
| Total cholesterol, mg/dL | 165 (150–180) | 162.5 (147.5–199) | 162.5 (156–169) | 0.99 |
| Triglycerides, mg/dL | 79 (63–102) | 100.5 (88.5–125) | 124 (114–134) | 0.015 |
| LDL-C, mg/dL | 90.5 (77–105) | 92.5 (79.5–115.5) | 84.5 (71–98) | 0.95 |
| HDL-C, mg/dL | 55 (49–61) | 54 (45–63) | 53 (48–58) | 0.68 |
| Plasma glucose, mg/dL | 102 (92–110) | 104.5 (98.5–113) | 101.5 (89–114) | 0.73 |
| Glycated haemoglobin A1c, % | 5.1 (5–5.3) | 4.95 (4.85–5.05) | 5.1 (5.1–5.1) | 0.32 |
| Serum creatinine, mg/dL | 0.97 (0.2) | 1.06 (0.2) | 1.11 (0.1) | 0.45 |
Data are n (%), median (IQR) for non-normally distributed data or mean (SD) for normally distributed data as determined by Shapiro-Wilk test.
*Pearson’s χ2 test, Wilcoxon rank-sum test or one-way analysis of variance (ANOVA).
BMI, body mass index; HDL-C, High-density lipoprotein; LDL-C, Low-density lipoprotein; NA, not applicable.