Table 1.

ECSERT inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
KTRs Prevalent KTR >1 year Male or female, aged >18 years old Willing and able to give informed consent for participation in the study Increased cardiometabolic risk with at least one of: Diabetes mellitus Dyslipidaemia Hypertension Obesity (BMI >30) History of ischaemic heart disease/cerebrovascular disease	Inability to give informed consent or comply with testing and exercise protocol for any reason Unable to undergo CMR scanning (incompatible implants, claustrophobia, allergy to agents, etc) Female participants who are pregnant, lactating or planning pregnancy during the course of the study Scheduled elective surgery or other procedures requiring general anaesthesia during the study Any other significant disease or disorder*
Healthy controls Age <18 years No documented history of major cardiorespiratory chronic condition None of the following cardiometabolic risk factors: Diabetes mellitus Dyslipidaemia Hypertension History of ischaemic heart disease/cerebrovascular disease Obesity (BMI >30) Not on any medication	Unable to undertake exercise testing due to physical or psychological barriers Scheduled elective surgery or other procedures requiring general anaesthesia during the study Inability to give informed consent or comply with testing and exercise protocol for any reason Any other significant disease or disorder*

*That is, significant comorbidity including unstable hypertension, potentially lethal arrhythmia, myocardial infarction within 6 months, unstable angina, active liver disease, uncontrolled diabetes mellitus (HbA1c ≥9%), advanced cerebral or peripheral vascular disease which, in the opinion of the patient’s own clinician, may either put the patient at risk because of participation in the study, or may influence the result of the study, or the patient’s ability to participate in the study.

BMI, body mass index; CMR, cardiac MRI; KTR, kidney transplant recipient.